The ZNF350/ZBRK1 Polyclonal Antibody, HRP Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The ZNF350/ZBRK1 Polyclonal Antibody, HRP Conjugated has been validated for the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
The transcpritional repressor ZBRK1, also designated zinc finger and BRCA1-interacting protein with a KRAB domain 1 or zinc finger protein 350, belongs to the Kr_ppel C2H2-type zinc-finger protein family of proteins. ZBRK1 localizes mainly to the nucleus and may be associated with the nuclear matrix. It is a widely expressed protein that binds to BRCA1. ZBRK1 plays an important role in transcriptional regulation. Likely targets of gene regulation are DNA damage response genes, which effect the survival and growth control of cells. ZBRK1 contains an N-terminal KRAB domain, a C-terminal BRCA1-binding region and eight central zinc-fingers